나눔터
공지사항
의학정보
복지정책
환우회소식
회비 및 후원금 납부내역
헌팅턴병 메뉴얼
HOME > 나눔터 > 의학정보

작성자
huntington [작성일 : 2016-07-13 16:07:42 ]   
제목 헌팅턴병 증상완화 신약관련 글 올립니다.

기존 tetrabenazine에서 개선 된 deutetrabenazine 에 대한 내용으로,

부작용이 다소 감소되었다고 하나 기존 테트라베나진과 비교 향상된 것인지는 좀 더 두고봐야할 것 같습니다. 테트라베나진과 성분이 거의 유사하여 기존 부작용들이 해결되지는 않았을 것 같은데 앞으로 좀더 개서되는 약들이 나오길 희망합니다.


아래 원문 첨부합니다.


New Drug Eases Huntington's Disease Symptoms - WebMd 7-7-2016

 

 

New Drug Eases Huntington's Disease Symptoms

 

http://www.webmd.com/brain/news/20160707/new-drug-eases-huntingtons-disease-

symptoms-study

 

Experimental med seems to have fewer side effects than current treatment,

researcher says

 

WebMD News from HealthDay

 

By Steven Reinberg HealthDay Reporter

 

THURSDAY, July 7, 2016 (HealthDay News) - An experimental drug may help

control the involuntary, sudden muscle movements associated with

Huntington's disease, with fewer side effects, according to the results of a

small trial.  "Deutetrabenazine is not yet FDA-approved, but assuming it

becomes available, practicing clinicians may have another choice for their

individual patients," said lead researcher Dr. Samuel Frank. He is a

neurologist and instructor at Harvard Medical School in Boston.

 

The involuntary movements associated with Huntington's disease are called

chorea. Huntington's disease is a fatal genetic disorder. It causes the

progressive destruction of nerve cells in the brain. Symptoms vary from

person to person. People who have Huntington's lose their physical and

mental abilities over 10 to 25 years. The disease has no cure, according to

the Huntington's Disease Society of America (HDSA). Every child with a

parent with Huntington's disease has a 50 percent chance of carrying the

faulty gene. Approximately 30,000 Americans have symptomatic Huntington's

disease. More than 200,000 are at risk of inheriting the disease, the HDSA

says.

 

The choice of drugs to treat chorea should be based on safety,

effictiveness, cost to patients and the best chance of compliance, Frank

said.  "The opportunity to possibly improve quality of life should be part

of the decision-making process as well," he said. "If approved by the FDA,

deutetrabenazine may provide another treatment option, making Huntington's

disease an increasingly treatable condition."

 

Funding for the trial was provided by the maker of the drug, Auspex

Pharmaceuticals, a subsidiary of Teva Pharmaceutical Industries, Ltd.

 

Currently, tetrabenazine

<http://www.webmd.com/drugs/drug-151522-tetrabenazine+oral.aspx>  (Xenazine

<http://www.webmd.com/drugs/drug-151569-xenazine+oral.aspx> ) is the only

drug approved by the U.S. Food and Drug Administration for treating chorea

in Huntington's disease, the study authors said. Although the drug is

effective, tetrabenazine often has to be taken three times a day and can

cause side effects, such as sedation, fatigue, anxiety or nausea, the

researchers said.

 

For the new study, Frank and his colleagues randomly assigned 90 patients

with Huntington's disease and chorea to receive either deutetrabenazine or a

placebo.

 

Over eight weeks, the dose of deutetrabenazine was increased to a level at

which it was most effective. That dose was maintained over four weeks, the

study authors said.

 

"We found that deutetrabenazine reduces chorea, the hallmark movement

disorder in Huntington disease," Frank said. "There was also an overall

improvement in participants' condition and improvement in a quality-of-life

measure. There was, however, no improvement in balance."  The rate of side

effects was similar for the drug and a placebo, which included depression,

anxiety and akathisia (a movement disorder), the researchers found.

 

The study findings were published July 5 in the Journal of the American

Medical Association. Frank said larger trials are underway to assess the

long-term safety and effectiveness of deutetrabenazine.

 

One neurologist said he would like to have seen a head-to-head comparison

between deutetrabenazine and tetrabenazine.  "I wish they had included a

tetrabenazine arm and a placebo arm," said Dr. Michael Geschwind. A

professor of neurology at the University of California, San Francisco, he

co-wrote an editorial accompanying the study results.

 

Such a trial is needed to see which drug is superior, Geschwind said. "But

for FDA approval, they only have to show it's better than placebo," he said.

Looking at this trial and another that compared tetrabenazine with a

placebo, Geschwind found that both drugs appeared to be equally effective.

However, deutetrabenazine had fewer side effects, he said.

 

"If a patient is doing well on tetrabenazine and tolerating it well, I

wouldn't consider changing it," Geschwind said. "But if I were starting a

new patient and the drugs were similar in cost, I'm probably going to go to

the new drug because out of the starting gate I'm probably going to have

less side effects."

 

===============================================

 

July 5, 2016, Vol 316, No. 1

Editorial | July 5, 2016 

 

Deutetrabenazine for Treatment of Chorea in Huntington Disease

 

JAMA. 2016;316(1):33-35. doi:10.1001/jama.2016.8011.

 

Authors: Michael D. Geschwind, MD, PhD1; Nick Paras, PhD1

[+-] Author Affiliations

<http://jama.jamanetwork.com/article.aspx?articleid=2531986>

 

In this issue of JAMA, the Huntington Study Group (HSG), First-HD study

investigators, reports findings from a randomized trial examining use of a

deuterated form of tetrabenazine, called deutetrabenazine, for treatment of

chorea in patients with Huntington disease.1

<http://jama.jamanetwork.com/article.aspx?articleid=2531986>  Tetrabenazine,

a vesicular monoamine transporter type 2 inhibitor that depletes monoamines

including dopamine, is used worldwide for the treatment of chorea and

dystonia. Tetrabenazine was approved by the US Food and Drug Administration

(FDA) for the treatment of chorea in Huntington disease, based on a prior

HSG study.2 <http://jama.jamanetwork.com/article.aspx?articleid=2531986>

 

First Page Review:

http://jama.jamanetwork.com/article.aspx?articleid=2531986

 

 

 

[ 새글 | 답글 | 수정 | 삭제 ] [ 목록 ]
[ 총게시물 : 37 | page : 2 ]
[ 정렬조건 : 등록일 | 조회  ]
순번 제목 조회 파일 등록일 작성자
17   김만호 교수님 세계헌팅턴병 학회 참관기를 올립니다. 814 16/03/03 운영자  
16   헌팅턴병 처방을 위한 치료제가 이제 곧 멀지 않았다는 내용의 기사글을... 3250 16/02/13 운영자  
15   바이러스 이용한 헌팅턴병 치료 연구글 소개합니다. 515 16/01/15 운영자  
14   치매 정복의 길 여는 치료제 2018년께 출시 1299 16/01/04 운영자  
13   세계 헌팅턴병 커뮤니티에서 발행하는 헌팅턴병 연구 소식지를 올립니다... 867 15/12/04 운영자  
12   전기자극을 이용한 헌팅턴병 증상 완화에 대한 글을 소개합니다. 742 15/11/30 운영자  
11   안티센스 올리고핵산(ASO; antisense oligonucleotide) 기술을 근간으로... 3621 15/11/23 운영자  
10   화이자 회사의 헌팅턴병 처치 약물 설명회에 대한 소개글 입니다. 751 15/11/11 운영자  
9   유전자 편집을 이용한 사람에서 최초 유전자치료 728 15/11/06 운영자  
8   헌팅턴병 새로운 약 승인과 기존 약에 대한 정보 소개합니다. 816 15/11/03 운영자  
7   헌팅턴병 동물 모델에서 유전자 조작을 이용한 치료 효과 확인 1140 15/10/30 운영자  
6   유전자 조절 치료제 약 개발에 대하여 803 15/10/26 운영자  
5   헌팅턴병 증상을 검사하는 새로운 방법에 대한 보고입니다. 713 15/10/20 운영자  
4   초기 헌팅턴병 치료를 위한 연구 소개글 입니다. 578 15/10/16 운영자  
3   '만능 줄기세포+유전자 가위'…유전성 정신지체 치료 길 열어 669 15/10/05 운영자  
2   헌팅턴병 간병 메뉴얼 (영문) 716 15/09/23 운영자  
1   헌팅턴병 병에 대해서 719 15/09/21 운영자  

1 2 [ 새글 | 처음목록 | 목록 ]  
단체명 : 헌팅턴병 환우회   주소 : 서울시 종로구 연건동 서울대학교병원 CMI  

Copyrightⓒ by huntington.co.kr All rights reserved.    webmaster  개인정보 취급방침